The objective of this study is to describe a target water–energy–food (WEF) nexus domain world including causal linkages and trade-off relationships between WEF resources and their stakeholders, and to develop a WEF nexus system map as an interdisciplinary tool used for understanding the subsequent complexity of WEF nexus systems. An ontology engineering method, which is a qualitative method, was applied for the replicability of the WEF nexus domain ontology and the map, because ontology engineering is a method of semantic web development for enhancing the compatibility of qualitative descriptions logically or objectively. The WEF nexus system map has three underlying concepts: (1) systems thinking, (2) holistic thinking, and (3) an integrated approach at an operational level, according to the hypothesis that the chains of changes in linkages between water, energy, and food resources holistically and systemically affect the WEF nexus system, including natural and social systems, both temporally and spatially. This study is significant because it allows us to (1) develop the WEF nexus domain ontology database, including defining the concepts and sub-concepts of trade-offs relating to WEF for the replicability of this study; (2) integrate the qualitative ontology method and quantitative network analysis method to identify key concepts serving as linkage hubs in the WEF nexus domain ontology; and (3) visualize human–nature interactions such as linkages between water, energy, and food resources and their stakeholders in social and natural systems. This paper also discusses future challenges in the application of the map for a science–policy–society interface.

Background: Perchlorate-induced natrium-iodide symporter (NIS) interference is a well-recognized thyroid disrupting mechanism. It is unclear, however, whether a chronic low-dose exposure to perchlorate delivered by food and drinks may cause thyroid dysfunction in the long term. Thus, the aim of this review was to overview and summarize literature results in order to clarify this issue. Methods: Authors searched PubMed/MEDLINE, Scopus, Web of Science, institutional websites and Google until April 2020 for relevant information about the fundamental mechanism of the thyroid NIS interference induced by orally consumed perchlorate compounds and its clinical consequences. Results: Food and drinking water should be considered relevant sources of perchlorate. Despite some controversies, cross-sectional studies demonstrated that perchlorate exposure affects thyroid hormone synthesis in infants, adolescents and adults, particularly in the case of underlying thyroid diseases and iodine insufficiency. An exaggerated exposure to perchlorate during pregnancy leads to a worse neurocognitive and behavioral development outcome in infants, regardless of maternal thyroid hormone levels. Discussion and conclusion: The effects of a chronic low-dose perchlorate exposure on thyroid homeostasis remain still unclear, leading to concerns especially for highly sensitive patients. Specific studies are needed to clarify this issue, aiming to better define strategies of detection and prevention.

A case study in the Solukhumbu region in northern Nepal reveals that the high number of seasonal tourists—which has doubled in 20 years—has led to growing water, food, and energy demands that have modified agropastoral practices and the use of local resources. This has induced new patterns in the movement of goods, people, and animals in the Everest region and the reconfiguration of the water–energy–food nexus. We use this concept of nexus to analyze ongoing interactions and transformations. Key changes involve (1) massive imports of consumer goods; (2) use of local resources with new techniques (hydropower plants, improved mills, greenhouses, and pipes for domestic networks) that depend on imported materials, which are newly accessible to Sherpas as a result of economic benefits generated by tourism; (3) commodification of local resources (water, hydropower, vegetables, fodder, and flour); (4) an increasing number of electrical appliances; and (5) new uses of water, especially for tourist-related services, including hot showers, watering of greenhouses, bottling of water, and production of electricity for cell phones, rice cookers, and other electric appliances. These new uses, on top of traditional ones such as mill operation, compete in some places during spring when water supplies are low and the tourist demand is high. A transfer of pressure from one resource (the forest) to another (water) has also resulted from the government ban on woodcutting, incentives to develop hydropower, and the competition between lodges to upgrade their amenities by offering better services (such as hot showers, plugs to recharge batteries, internet connections, and local vegetables). Our research finds that water is now central to the proper running of the tourist industry and the region's economy but is under seasonal pressure.

Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare reported energy and macronutrient intake. This study was conducted within the pilot study of the Swedish CArdioPulmonary bioImage Study (SCAPIS), which included 1111 randomly selected men and women aged 50–64 years from the Gothenburg general population. Of these, 200 were enrolled in the SCAPIS diet substudy. TEEDLW was measured in a subsample (n 40). Compared with TEEDLW, both methods underestimated energy intake: −2·5 (sd 2·9) MJ with the Riksmaten method; −2·3 (sd 3·6) MJ with MiniMeal-Q. Mean reporting accuracy was 80 and 82 %, respectively. The correlation between reported energy intake and TEEDLW was r 0·4 for the Riksmaten method (P < 0·05) and r 0·28 (non-significant) for MiniMeal-Q. Women reported similar average intake of energy and macronutrients in both methods whereas men reported higher intakes with the Riksmaten method. Energy-adjusted correlations ranged from 0·14 (polyunsaturated fat) to 0·77 (alcohol). Bland–Altman plots showed acceptable agreement for energy and energy-adjusted protein and carbohydrate intake, whereas the agreement for fat intake was poorer. According to energy intake data, both methods displayed similar precision on energy intake reporting. However, MiniMeal-Q was less successful in ranking individuals than the Riksmaten method. The development of methods to achieve limited under-reporting is a major challenge for future research.