Structural changes in the germ epithelium of juvenile rat testicles after DL-thyroxine treatment
1993
Stosic-Bogdanovic, N. | Radovanovic, A. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia). Department of Histology and Emryology)
The experiments were performed with juvenile Albert Oxford rats in which hypothyroidism had been induced by injection of DL-thyroxine. The study showed that DL-thyroxine treatment at a critical postnatal period of brain development and maturation impaired the normal growth of animals and testicles and at the same time retarded the first normal spermatogenesis. Abnormal changes were demonstrated at the level of the testicle germ epithelium, accompanied by fine cellular alteration in the pachytene spermatocytes. The number of seminiferous tubules which contained zygotene spermatocytes were increased, but the number of tubules with more differented germ epithelium cells-spermatids were significantly reduced.
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