PCR genotyping of the ryanodine receptor gene RYR1 in Yugoslav meat swine
1996
Sarac, M. (Scientific Institute for Veterinary Medicine, Novi Sad (Yugoslavia)) | Jovanovic, S. | Gagrcin, M.
The results of the present study on Yugoslav meat breed swine using the PCR/restriction endonuclease test (DNA test) confirm the hypothesis of Fujii and Otsu (1991) that the cause of malignant hyperthermia (MH) is a mutation at nt 1843 in the RYR1 gene. Mutation in the RYR1 gene is present in Yugoslav meat swine in the heterozygous state. The frequency of the RYR1 (C) allele is 0.90 and RYR1 (T) is 0.1. Development of a definitive diagnostic test for susceptibility to PSS (porcine stress syndrome) is a major objective of research and cost-effective application in the swine selection programe.
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