Acceleration of the penetration of rabies virus vaccination strain Vnukovo-32 by DEAE-dextran at oral administration to suckling mice
1998
Ondrejka, R. | Svrcek, S. | Benisek, Z. | Durove, A. | Sueliova, J. (Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic))
The influence of DEAE-dextran on acceleration of the penetration of Vnukovo-32 vaccination strain was investigated in oral application experiments on suckling mice. The method of cryostat sections of organs and sections stained by the direct immunofluorescence method for detection of rabies antigen was used. The results of experiments confirmed that DEAE-dextran has an accelerating effect on the penetration of attenuated vaccination strain of rabies virus. Conditions for utilization of this knowledge for oral antirabies vaccination have been created.
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