Antifungal substance from Thai medical plant Anaxogorea luzonensis
1993
Vilai Santisopasri | Kato, H. | Kodama, O. (Kasetsart Univ., Bangkok (Thailand). Faculty of Science. Dept. of Biochemistry)
In our search for some bioactive substances for pest control from tropical plants growing in Thailand, we found that 70 % methanol extract of Anaxogorea luzonensis, a Thai folk medicinal plant, exhibited strong antifungal activity. The five purified active substances were obtained after employing several steps of solvent extraction and chromatography techniques. These substances designated as A1-A, B, C, D, E possessed strong inhibitory activity against the spore germination of Pyricularia oryzae, a fungus causing rice blast disease with the ED50 values of 1.8, 18, 3.5, 1.2 and 1.5 ppm respectively. The structure of A1-A was elucidated by mass spectrometry and UV, IR, NMR spectrometry as 1, 3, 5-trihydroxy-4-(3-methyl-2-butenyl)-9H-xanthen-9-one.
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