Effect of high levels of sodium selenite on activity of certain enzymes in blood plasma of chicks

Todorovic, M.; Mihailovic, M.; Hristov, S.

Effect of high levels of sodium selenite on activity of certain enzymes in blood plasma of chicks

1998

Todorovic, M. (Poljoprivredni fakultet, Beograd - Zemun (Yugoslavia)) | Mihailovic, M. | Hristov, S.

There were determined the effect of the addition of high levels of sodium selenite (0, 2, 5, 10, 15, 20 or 30 mg Se/kg feed) on the activity of glutathione peroxidase (GSH-Px), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood plasma of chicks during fattening. The addition of high levels of nonorganic selenium to chick feed did not lead to a linear increase in GSH-Px activity. In all groups, the highest levels of GSH-Px were on the 11th day (11.40-36.76 microkat/L). Already toward the end of the 2nd week, a significant drop was in enzyme activity in all groups (9.10-27.40 microkat/L). Activity was decreased in proportion with the duration of exposure. AST activity in chick plasma was almost equal in all groups (92.90-137.30 U/L) in certain time intervals. The only exceptions are groups 5 and 6, where significantly higher values were at the end of the 5th and 6th weeks of fattening (178.70-197.00 U/L). At the age of 11 days, ALT activity in all chick groups was at almost the same level (12.50-15.70 U/L), with exception of group 3, which showed higher activity (19.00 U/L). At the end of the 2nd week, enzyme activities in all groups almost doubled in comparison with the situation established on the 11th day (25.70-33.75 U/L). However, at the end of three weeks, there was a significant drop in ALT activity to values which were lower than those established on the 11th day (5.15-11.60 U/L). Enzyme activity was maintained at these levels throughout the fattening period.

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