In vitro induction of micronuclei in sheep and bovine lymphocytes after exposure to chloridazon
1998
Piesova, E. (University of Veterinary Medicine, Kosice (Slovakia))
The effect of the herbicide chloridazon on induction of micronuclei (MN) in sheep and bovine peripheral lymphocytes was evaluated in vitro. Chloridazon affected micronuclei (MN) at all the concentrations tested: 7 x 10E-6 M, 7 x 10E-5 M, and 7 x 10E-4 M. A statistically significant increase of MN was seen in sheep and bovine lymphocytes at a chloridazon concentration of 7 x 10E-4 M (P0.01 and P0.001, resp.). No significant differences in induction of MN were found at both lower concentrations tested. The results indicated that chloridazon exerted only a weak influence on induction of the chromosomal changes (MN) observed.
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