Effect of kabosu juice precipitate on lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP) fed a cholesterol diet
1998
Ogawa, H. (Kinki Univ., Higashiosaka, Osaka (Japan). Faculty of Medicine) | Mochizuki, S. | Meguro, T.
To elucidate the hypocholesterolemic mechanism of Kabosu juice residue (an ethanol-precipitated fraction of Kabosu juice: KJR), we investigated the effects of KJR on lipid metabolism in the serum and liver using male stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model. Six rats, 7 weeks of age, were fed on a high-Cholesterol diet containing KJR for 2 weeks. The increase in serum total cholesterol was markedly suppressed in comparison with the control group (N=6), due to suppression of increases in the very-low-density lipoprotein and low-density lipoprotein fractions. The concentration of serum apolipoprotein (apo) A-I was significantly decreased and that of serum apoA-IV was significantly increased, while no change was observed in the lipid content of the high-density lipoprotein (HDL) fraction, suggesting an alteration of HDL composition. In the liver, increases in the contents of cholesterol and triglyceride were markedly suppressed. In addition, the activities of cholesterol 7 alpha-hydroxylase [EC 1.14.13.17] and acyl-CoA: cholesterol acyltransferase [EC 2.3.1.26] were significantly low
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