Effect of vitamin E on disease resistance and specific immune response of hybrid catfish
1998
Suneerat Cheansanoi
Studies on the effect of vitamin E (alpha-tocopherol acetate) on disease resistance and specific immune response of hybrid catfish (female Clarias macrocephalus Gunther X male Clarias gariepinus Burchell) were conducted. Hybrid catfish with average weight of 1.53+-0.03 g were fed with diet containing vitamin E at 74.40, 121.05, 251.45 and 499.75 mg/kg diet for four weeks and then challenged by intraperitoneal injection of virulent Aeromonas hydrophila. There were significant differences amongst the survival rate after 72 hours post challenge in which hybrid catfish fed with 499.75 mg/kg had the highest survival rate (P0.05). Study on the effect of vitamin E on specific immune response was conducted with hybrid catfish with average weight of 66.50+-1.55 g. They were fed with diet containing vitamin E at 70.30, 181.70, 260.50 and 501.40 mg/kg diet for four consecutive weeks and then immunized twice by intraperitoneal injection of formalin-killed A. hydrophila vaccine. Antibody titer in serum was determined weekly which indicated that there was no significant difference amongst all experimental groups in term of the titer values within each sampling period for both primary and secondary immune response. Titer of all experimental groups reached peak a weed after and second immunization. Based on this study, it can be suggested that resistance to A. hydrophila infection in hybrid catfish can be improved by vitamin E at the rate of 499.75 mg/kg. However, at any level of this vitamin did not improve specific immune response to A. hydrophila vaccine in term of serum antibody titer. Disease resistance enhancement should be due to better activity of serum antibody titer. Disease resistance enhancement should be due to the better acitivity related to non-specific immune response such as phagocytosis of this hybrid catfish.
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