Health risk assessment in consuming fish contaminated with organochlorine insecticides from the Chao Phraya river at Bang Krabeng community, Tambon Bang Luang, Amphoe Sapphaya, Changwat Chai Nat

This research is aimed to study about health risk assessment in consuming fish cuntaminated with organochlorine insecticides from the Chao Phraya River at Bang Krabeng community by following NRC. Thus, the study started by reviewing hazard identification and dose response to assess health risk of people who exposed to organochlorine insecticides such as chlorinated ethane (DDT, DDD and DDE). cyclodienes (endrin, aldrin, dieldrin, heptachlor and heptchlor epoxide) and hexachlorocyclohexane (alpha-,beta-, gamma- and delta-HCH). The totals of 44 samples were collected from 244 fish (29 species) in 4 months during January to December 1997 and were analyzed by chromatographic procedure. The average concentration of total organochlorine insecticide residues in fish was 0.0099 mg/kg which the chlorinated ethane, cyclodienes and HCH were 0.0068, 0.0019 and 0.0011 mg/kg, respectively. It was concluded that the total of human exposure in consuming fish contaminated with organochlorine insecticides in all lifetime was 2.33E-06 mg/kg/day which the total of human exposure of chlorinated ethane, cyclodienes and HCH were 1.6E-06, 4.72E-07 and 2.59E-07 mg/kg/day, respectively. The results of the total noncarcinogen risk were 0.0059 that they were lower than the standard of USEPA. However the results of the total carcinogen risk was 5.68E-06 which was higher than the acceptable standard of USEPA. It also revealed that the probability of carcinogenesis was about 5.68 persons in 1 million persons when they consume contaminated fish in all lifetime. By comparing to the acceptable standard of USEPA must not be higher than 1E-06 (not exceeded more than 1 person in 1 million persons). In addition to the results of carcinogen risk, it also revealed that the cyclodienes were higher risk than HCH and chlorinated ethane. The carcinogen risk of chlorinated ethane cyclodienes and HCH were 4.81E-07, 4.57E-06 and 6.33E-07, respectively. For closer consideration, cyclodienes was more influence to carcinogenesis than other groups. Due to cyclodienes had carcinogenic potency higher than the another ones, although they were exposed lower than chlorinated ethane. So the carcinogenic potency of them were caused carcinogen risk more than the human exposure in this community.