Prostanoid synthesis in the cerebral blood vessels of asphyxiated piglets
2001
Kis, B. | Mezei, Zs. | Forgacs, P. | Gecse, A. | Telegdy, Gy. | Bari, F.
The aim of this study was to examine the effects of asphyxia-reventilation and hyperoxia on the cerebral blood perfusion and prostanoid production of the brain arteries and microvessels in piglets. After 10 min of asphyxia, animals were ventilated with room air, or with 100% dioxid. Following 4 hours of recovery, the brains were perfused, cerebral arteries were removed and microvessels were isolated from the cortex. Under control conditions, the synthesis of dilatory prostanoids dominated the arachidonate cascade both in the microvessels and in the arteries. Asphyxia and reventilation with room air did not modify the prostanoid production.
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