Antioxidation and Anticancer Effects of Polyozellus multiplex
2000
Han Jung | Lee In-Seon Keimyung University, Taegu (Korea Republic)
This study was carried out to investigate the antioxidative and chemopreventive effects of the extracts from Polyozellus multiplex, an edible mushroom through in vitro and in vivo assay. Polyozellus multiplex fractions were assayed for its antioxidative effect with colony formation assay. Polyozellus multiplex methanol extract and water fraction showed protective effects against the cytotoxicity of H2O2. The modifying effects of Polyozellus multiplex methanol extract and water fraction on the induction of carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in Wistar rats. The GSH content was decreased by MNNG treatment but was increased by adding Polyozellus multiplex water fractions. Also the activity of glutathione S-transferase and the superoxide dismutase levels were increased by the treatment of Polyozellus multiples water fractions more than with MNNG alone. In addition to the Polyozellus multiplex water fraction increased the p53 expression as compared with the value of MNNG alone.
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