Therapeutic effects of fumagillin and first appearance of Nosema apis spores following infection
2000
Mladjan, V. (Institute of Veterinary Medicine of Serbia, Belgrade (Yugoslavia)) | Todorovic, D. | Lolin, M.
The therapeutic effect of Fumagillin after artificial infection of bees with Nosema apis spores was investigated. The appearance of spores and development stages of Nosema apis in the midgut after infection was detected pathohistologically. Three groups of bees were set up: Group A was artificially infected with Nosema apis spores in sugar syrup; Group B - on the 8th day following infection bees were administered sugar syrup with Fumagillin. The first application included 0.005 g Fumagillin DCH in 20 ml of syrup. Identical therapy was repeated two more times at intervals of 4 days. Group C consisted of healthy bees, not artificially infected, serving as controls. Pathohistological examinations showed the first appearance of spores and various stages of Nosema apis already two days after artificial infection. The Fumagillin therapy gave only a short-term improvement in the health of bees intected with Nosema disease. The infective process then continued to progress with a sudden increase in the number of spores in the midgut.
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