Role of innate defence mechanisms in acute phase response against gram-negative agents
2002
Andonova, M. (Trakia University, Stara Zagora (Bulgaria))
The role of innate defence mechanisms - humoral and cellular, in a Gram-negative infection is studied. The species-related contradiction about the changes in lysozyme, complement and phagocyte activities and the possibility for using them as important indicators for the severity of disease discussed. A particular attention was paid to microbicide mechanisms of phagocytes - oxygen radicals and nitric oxide as well as to the regulatory mechanisms for prevention of the negative effects due to their pathological increase.The key role of cytokines for the formation of local and generalized manifestations of systemic acut phase response after a Gram-negative infection is outlined too.
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