Effect of different routes of vaccination against new-castle disease on lymphoid organs of broilers
2003
Salam, R. | Aslam, A. | Khan, S.A. (University of Veterinary and Animal Sciences, Lahore (Pakistan). Dept. of Pathology) | Saeed, K. | Saleem, G.
This project was designed to compare two routes (intraocular and drinking water) of vaccination against Newcastle disease in terms of protection against velogenic field isolate of Newcastle disease virus (NDV). The immune response and morphological changes in lymphoid organs (Harderian gland, bursa of fabricius and thymus) of broilers were noted. The role of Harderian gland to generate local and humoral immunity in response to eye drop and drinking water vaccination against NDV was also evaluated. This experiment showed that ocular vaccination resulted in significantly high level of circulating antibodies as compared to drinking water vaccination. No histopathological changes were observed in lymphoid organs after NDV challenge in jocularly vaccinated birds. There were significantly (P less than 0.05) higher number of plasma cells in sections of Harderian gland after eye drop vaccination. It was concluded that ocular vaccination stimulated Harderian gland to produce strong local protective immunity in ocular as well as in oral mucosa.
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