Acute toxicity and efficacy of Psidium guajava leaves water extract on Salmonella typhi infected wistar rats
2003
Etuk, E.U. (Usmanu Danfodiyo Univ., Sokoto (Nigeria). Pharmacology Dept.) | Francis, U.U.
The acute toxicity and efficacy of Psidium guajava leaves water extract on Salmonella typhi infected wistar rats had been studied. Oral administration of 10-50 mg/100 g of the extract showed no significant harmful effect in the animals after 72 h. The administration of 10-30 mg/100 g of the extract 12 h through the same route to rats infected with Salmonella typhi produced a recovery within seven days. The Salmonella infection equally responded to chloramphenicol, a conventional antibiotic used in the treatment of this infection. These results suggested that the water extract of Psidium guajava leave was non toxic at the tested doses and effective against Salmonella infection in wistar rats.
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