Formation of the corpus luteum and luteolysis
2001
Snoj, T. (Insemination Centre Preska, Medvode (Slovenia))
Growth of the corpus luteum is influenced by many factors: LH, PGE, PGI, IGF-1, EGF, oxytocin. Blood vessels in corpus luteum are inervated by adrenergic nerves. Noradrenaline (NA) binding to - adrenergic receptors in blood vessels of the corpus luteum regulates blood flow, whereas NA binding to - adrenoreceptors in luteal cells influences steroidogenesis. GF2 causes luteolysis. PGF2 stimulates synthesis of the endotelin-1 and nitric oxyde synthase (NOS) which cause structural luteolysis. PGF2 also blocks the synthesis of the progesterone (functional luteolysis).
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