Genotoxic effects of formaldehyde on the cultured human lymphocytes
2002
Liman, B.C. | Liman, N. | Ozkul, Y. | Hamurcu, Z. (University of Erciyes, Kayseri (Turkey). )
Formaldehyde is being widely used both in industrial and medical applications, Formaldehyde is a normal metabolite in the mammalian systems. It occur in the atmosphere as a product of natural photooxidation of automobile exhaust, combustion processes, incinerators; formaldehyde has been found in munipicial and industrial effluents and is present in the food either naturally (fruits and vegetables, in the order of parts per million), or as a result of its use as food additive. It was demonstrated that the formaldehyde is a mutagen and a carcinogen in the laboratory animals and cultured haman cells. In this study, the genotoxic effect of formaldehyde on the frequency of micronuclei in the cultured lymphocytes of healthy volunteers was examined.
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