Study the prevalence of previous HBV infection among the patients of anti HCV positive chronic liver disease
2004
Imtiaz, F. (Aga Khan Univ., Karachi (Pakistan). Dept. of Pathology and Microbiology) | Hasan, S.M.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) both leads to chronic liver disease (CLD). It is observed that patients positive for anti HCV with CLD frequently show markers of previous HBV infection. The aim of present study is to assess the prevalence and clinical association of previous HBV infection in the patients of anti HCV positive, hepatitis B surface antigen (HBsAg) negative with various degree of CLD seen at tertiary care hospitals. The observations indicate that 84.5% patients showed markers of previous HBV infection. This feature was more frequent (p=0.01) among chronic hepatitis patients (47.5%) as compared to 28% of cirrhotic patients. Chronic hepatitis patients with previous positive marker for HBV infection showed worse histological picture as compared to those who were negative for previous HBV infection. The 2% patients showed minimal changes, 47.5% showed chronic hepatitis and 28% were showed cirrhosis pattern on histological findings. Among these patients 169 (84.5%) are those who had both anti HBc and anti HCV positive, showed worse stage of disease and confirmed by histological procedures. Our observations suggested that HCV patients in the presence of previous HBV infection showed worse stage of the disease.
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