Study on effects of different levels of ethanol through drinking water on haematology, lymphoid organs and immune response in broiler chicks
2002
Khan, I.A.
One hundred and fifty day-old broiler chicks were procured and randomly divided into five groups viz. A, B, C, D and E each having 30 chicks. Group E served as control receiving no treatment. Groups A, B, C, and received ethanol through drinking water at the dose rate of 2, 4, 8 and 16% V/V respectively. A significant or relative increase (P less than 0.05) in the erythrocyte count of all treatment groups was observed, while packed cell volume and erythrocyte sedimentation rate showed non significant difference in treatment groups as compared with control. However, Haemoglobin concentration showed a decrease in the treated broilers. A significant decrease (P less than 0.05) in live weight of broilers received different dose levels of ethanol up to the age of 42 days was observed with a gradual decreasing trend in the live body weight. A significant decrease (P less than 0.05) in relative weights of lymphoid organs including spleen, bursa of Fabrics and thymus were observed cell volume through out the treatment trial. However, no gross pathological changes were observed in the lymphoid organs. There was a comparable decrease in the cellular density in the treated groups at histological examination under light microscope in all the treatment groups. Total leukocyte count of broilers received ethanol showed an overall decrease while hetrophil percentage showed an increase throughout the treatment trial. Similarly lymphocyte percentage was lower in treatment groups during the experimental trials. However, other cells including eosinophils and monocytes showed non- significant difference between the treatment groups and control. Serum antibody titers against NDV, IBDV and washed sheep red blood cells were lower in broilers received ethanol as compared with the control. Similarly there was a significant decrease in the cell mediated immune response in the broilers against the mallein antigen in treated groups.
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