Effects of aggregation of nuclear-transferred mouse embryos developed from enucleated eggs receiving ES cells on in vitro and in vivo development
2002
"Yabuuchi, A. (Kinki Univ., Higashiosaka, Osaka (Japan). Faculty of Agriculture) | Kato, Y. | Tsunoda, Y. "
"Nuclear-transferred mouse eggs receiving embryonic stem cells develop into blastocysts at a high rate, but their potential to develop into fetuses is very low. Therefore, the present study examined the effects of aggregating of two nuclear-transferred eggs at the 8-cell stage to increase the cell number of nuclear-transferred embryos. The proportion of implantation sites on gestational day 10.5 after transfer of aggregated nuclear-transferred embryos (53%) was significantly higher than after single nuclear transfer (29%) or serial nuclear-transfer (37%). The proportion of implantation sites with fetuses did not differ significantly among the three groups (7 to 17%). These results demonstrate that the low potential of nuclear-transferred embryos with embryonic stem cells to develop into fetuses is not due to the lower cell number of nuclear-transferred embryos."
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