Antibiotic sensitivities of Mycobacterium avium isolated from pigs and the diagnostic significance of IFN-gamma produced by lymphocytes stimulated with a specific antigen in swine mycobacteriosis
2004
Iwakiri, A. (Miyazaki-ken. Government Office (Japan)) | Gannithida, S. | Ogata, I. | Yamamoto, S. | Goto, Y.
SUMMARY Multiplex PCR tests identified 69 strains of mycobacteria originated in pigs from 5 Japanese meat-inspection centers as Mycobacterium avium (M. avium). The sensitivities of 24 strains to 9 antibiotics were tested. All strains were shown to be 8 times more sensitive to streptomycin, rifampicin, clarithromycin, and amikacin than is indicated by previously reported data on M. avium strains originating in human beings [10] . Measurements of interferon-gamma (IFN- g) production by spleen cells or blood monocytes isolated from normal or infected pigs showed that IFN- g was produced in the swine-mycobacteriosis group if they were stimulated by the M. avium antigen in vitro. No production was observed in the healthy control group. This suggests that IFN-g assay is a valuable method for diagnosis of M. avium infection in swine.
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