An in vitro chemosensitivity test against canine mammary gland tumors using collagen gel droplet embedded cultures
2004
Kitagawa, H. (Gifu Univ. (Japan)) | Ohba, Y. | Watanabe, K. | Fukata, T. | Takano, T. | Kobayashi, H. | Kitoh, K. | Yamazoe, K.
SUMMARY Our basic study on the usefulness of the collagen gel droplet embedded culture drug-sensitivity test (CD-DST) showed that canine mammarygland tumor cells can be cultured well in collagen gel droplets. With this method, we employed five kinds of anticancer drugs-adriamycm, 40H-cyclophosphamide, vincristine, 5-fluo-rouracil, and predonisolone-against tumor cells. An image-analysis system was used to analyze their in vitro anticancer activities. We found that anti-cancer drug efficacy against canine mammary gland tumors differed from dog to dog. The CD-DST method can be applied to canine tumors and may be an index for so-called custum-made therapy.
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