Intestinal immune response of weaned pigs experimentally vaccinated with F4ac+ non-enterotoxigenic strains of Escherichia coli
Vijtiuk, N.(University of Zagreb (Croatia))E-mail:[email protected] | Sver, L. | Lackovic, G. | Popovic, M. | Bozic, F. | Valpotic, I.
The potential effects of two adjuvants, the copolymer of polyoxyethylene-polyoxypropylene (POE-POP) and N-acetylglucosaminyl-(beta,1-4)-N-acetyl-muraminyl-L-alanyl-D-isoglutamine (GMDP), on mucosal humoral and cell-mediated immune responses were tested in weaned pigs immunized with the F4ac+ non-enterotoxigenic Escherichia coli (non-ETEC) strain 2407 and challenged with the F4+ ETEC strain 11-800/1/94. Approximately 75% of 2407+POE-POP-treated pigs and 50% to 60% of pigs that were immunized with either the 2407+GMDP or the 2407 strain alone, respectively, were positive for anti-F4ac sIgA antibodies. The T cell antigen CD3a was expressed in 2407+GMDP or 2407-treated pigs. The B cells expressing a CD21 surface molecule were present in 2407-treated pigs. A strong reaction to sIgA was determined in pigs immunized with the 2407 strain. Oral immunization of weaned pigs with the F4ac+ non-ETEC strain may induce the priming of intestinal immune cells.
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