Dietary resistant starch alters the characteristics of colonic mucosa and exerts a protective effect on trinitrobenzene sulfonic acid-induced colitis in rats
2004
Morita, T. (Shizuoka Univ. (Japan). Faculty of Agriculture) | Tanabe, H. | Sugiyama, K. | Kasaoka, S. | Kiriyama, S.
The protective effect of a dietary high-amylose cornstarch (HAS) against trinitrobenzene sulfonic acid (TNBS)-induced colitis was examined in rats. Rats were fad a HAS-free basal diet or, a 15% or 30% HAS supplemented diet for 10d, and then received intracolonic TNBS to induce colitis and fed the respective diets for a further 8d. HAS ingestion stgnificantly protected colonic injuries as evidenced by lower colonic myeloperoxidase activity. Rats fed the HAS diet showed greater cecal short-chain fatty acid (SCFA) production tban those fed the basal diet. Further, Just before TNBS administration, HAS ingestion dose-dependently in creased fecal and cecal mucin contents, and protein and nucleic acid contents in the colonic mucosa HAS ingestion also reduced colonic permeability. The protective effect of HAS ingestion on TNBS-induced colitis is perhaps exerted through alterations in colonic mucosa, possibly due to cecal SCFA production.
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