Phagocytic activation of monocytes by C-UP III herbal polysaccharides in calves and cows
2006
Yoshida, S.(Yamanouchi Pharmaceutical Co. Ltd., Tokyo (Japan)) | Nakanishi, N. | Yamada, K.
Phagocytic activity of monocytes derived from cows and calves administered a mixture of plant polysaccharides called C-UP III was examined by measuring the number and rate of cells that phagocytosed latex beads. The phagocytic activity of monocytes in cows, which had been given 5, 10, 20 or 50 g/day of C-UP III for three consecutive days, began to increase at three days after the start of administration and peaked after seven days. Phagocytic activity remained high for two weeks. The extent of these increases in phagocytic activity was similar in cows administered with 10-50 g/day of C-UP III. In calves, C-UP III was administered for 21 consecutive days from the seventh postnatal day, either orally at 3 or 6 g/day or via artificial milk formula containing 6 g/day of C-UP III. The number of phagocytosed latex beads per cell increased in each of these calves similarly, and it was higher than that of the control group at 21 days after the start of C-UP III administration. In calves orally administered with C-UP III, the rate of phagocytosis increased from seven days after the start of C-UP III administration and continued to increase at similar rates. When C-UP III was given with milk, the rate of phagocytosis was also elevated but was not as high as that of oral administration.
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