Inhibitory Effects of(-) Epigallocatechin Gallate and Quercetin on High Glucose-induced Endothelial Cytotoxicity
2006
Choi, Y.J. (Hallym University, Chuncheon, Republic of Korea) | Kwon, H.M. (Hallym University, Chuncheon, Republic of Korea) | Choi, J.S. (Hallym University, Chuncheon, Republic of Korea) | Bae, J.Y. (Hallym University, Chuncheon, Republic of Korea) | Kang, S.W. (Hallym University, Chuncheon, Republic of Korea) | Lee, S.S. (Hallym University, Chuncheon, Republic of Korea) | Lee, Y.J. (Chuncheon Bioindustry Foundation, Chuncheon, Republic of Korea) | Kang, Y.H. (Hallym University, Chuncheon, Republic of Korea), E-mail: [email protected]
Functional damage to microvascular endothelial cells by hyperglycemia is thought to be one of the critical risk factors in the impaired wound healing seen with diabetes mellitus. It is also thought that oxidative stress plays a significant role in this endothelial cell dysfunction. The present study the differential effects of flavonoids on endothelial cell dysfunction under high glucose conditions. Human endothelial cells exposed to 30mmol/L glucose for 7d were pre-treated with various flavonoids and pulse-treated with 0.2 mmol/L H₂O₂ for 30 min.
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