Effects of Copper, Zinc and Cadmium on the Recovery Pattern of Aryl Sulfotransferase Ⅳ Activity in Rats fed 2-Acetylanminofluorene Diet
2006
Chung, K.H. (Sahmyook University, Seoul, Republic of Korea), E-mail: [email protected] | Ringer D.P. (American Cancer Society, Atlanta, GA. U.S.A.) | Shin, K.O. (Sahmyook University, Seoul, Republic of Korea)
Purified rat liver aryl sulfotransferase Ⅳ (AST Ⅳ) was found to be inhibited in vitro by zinc, copper, cadmium and terbium. Among these four elements, zinc, copper and cadmium were all strongly inhibitory to the AST Ⅳ activity at very low concentrations (2.5 ㎛ to 0.025 ㎛). In rat liver cytosol, zinc, copper and cadmium at 25 ㎛ to 0.025 ㎛ also decreased the AST Ⅳ activity to 50% of the controls. In order to assess the possible effects of these metals on the AST Ⅳ activity recovery pattem in vivo, studies on the relationship between these minerals and dietary 2-acetylaminofluorene were conducted.
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