Identification of novel Leishmania major antigens that elicit IgG2a response in resistant and susceptible mice
2006
Mohammadi, M.R. (Institute of Biochemistry and Biophysics, University of Tehran, Tehran.) | Zeinali, M. (Institute of Biochemistry and Biophysics, University of Tehran, Tehran.) | Ardestani, S.K. (Institute of Biochemistry and Biophysics, University of Tehran, Tehran.), E-mail: [email protected] | Kariminia, A. (Department of Immunology, Pasteur Institute of Iran, Tehran, Iran)
Experimental murine models with high, intermediate and low levels of genetically based susceptibility to Leishmania major infection reproduce almost entire spectrum of clinical manifestations of the human disease. There are increasing non-comparative studies on immune responses against isolated antigens of L. major in different murine strains. The aim of the present study was to find out whether there is an antigen that can induce protective immune response in resistant and susceptible murine strains. To do that, crude antigenic extract of procyclic and metacyclic promastigotes of L. major was prepared and subjected to SDS-PAGE electrophoresis.
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