Inhibition of Tyrosine Hydroxylase by (1R,9S)-β-Hydrastine Hydrochloride in PC12 cells
2004
Yin, Shou Yu (Yanbian University, Yanji, Jilin, P.R. China) | Kim, Y.M. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, J.J. (Chungbuk National University, Cheongju, Republic of Korea) | Jin, C.M. (Chungbuk National University, Cheongju, Republic of Korea) | Yang, Y.J. (Chungbuk National University, Cheongju, Republic of Korea) | Lim, K.W. (Chungbuk National University, Cheongju, Republic of Korea) | Kang, M.H. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, M.K. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected]
It is reported that (1R,9S)-β-Hydrastine hydrochloride (BHSH) decreased the intracellular dopamine content by inhibiting tyrosine hydroxylase (TH) activity in PC12 cells. In this study, the inhibitory mechanisms on TH activity by BHSH in PC12 cells were investigated. BHSH treatment caused a reduction of TH activity and TH mRNA level in a dose-dependent manner. After the treatment of 20 μM BHSH, TH activity and TH mRNA content were reduced at 15min, reached the minimal levels at 6-24h, and then recovered gradually to the control level.
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