Establishment of Short-term Screening Test for Detecting Testicular Toxicity in Rats: 2-Bromopropane as An Example
2005
Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea), E-mail: [email protected] | Park, S.C. (Kyungpook National University, Daegu, Republic of Korea) | Cha, S.W. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Shin, J.Y. (Kyungpook National University, Daegu, Republic of Korea) | Shin, D.H. (Kyungpook National University, Daegu, Republic of Korea) | Kim, S.H. (Kyungpook National University, Daegu, Republic of Korea) | Bae, C.S. (Kyungpook National University, Daegu, Republic of Korea) | Kang, B.H. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Chung, M.K. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea)
The present study was performed to establish a short-term screening test for detecting testicular toxicity of chemicals in rats and to determine whether a 2-week administration period is sufficient to detect testicular toxicity of 2-bromopropane (2-BP) as an example. Male Sprague-Dawley rats were subcutaneously administered with 1000 mg/kg/day of 2-BP or its vehicle (corn oil) for 2 weeks. Ten male rats each were sacrificed on days 3, 7 and 14 after the initiation of treatment. Parameters of testicular toxicity included genital organ weights, testicular sperm head counts, epididymal sperm counts, motility and morphology, and histopathologic examinations.
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