Effects of a Selective COX-2 Inhibitor Celecoxib and Soy-Isoflavones on Molecular Markers Related to Apoptosis, and COX-2 and Mapkinase Expression in Estrogen-Fed Rats
2005
Kim, T.K. (Hannam University, Daejeon, Republic of Korea) | Park, O.J. (Hannam University, Daejeon, Republic of Korea)
The present study examined the effects of cyclooxygenase-2 (COX-2) inhibitor celecoxib or soy-isoflavones in the presence of estrogen on apoptosis related gene expression, COX-2 and mapkinase in 48-week old female rats. Expressions of bcl-2 and bax proteins, which are known to be involved in the regulation of apoptosis, were investigated in mammary glands and heart tissues. The elevated expression of bcl-2 expression was observed in mammary glands of celecoxib supplemented rats as well as soy-isoflavones.
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