Chromatographic Fractionation Patterns of Deoxyribonucleases Secreted from Haemonchus contortus Adult Worms
2006
Kwak, D.M. (Kyungpook National University, Daegu, Republic of Korea), E-mail: [email protected]
Genomic DNA fragmentation was induced in intestinal cell nuclei of Haemonchus contortus by treatment of fenbendazole anthelmintic. Elucidating mechanisms to induce DNA fragmentation by an ectopic treatment might identify a novel way to induce irreparable damage to parasites. Since enzymatic deoxyribonucleases (DNases) are common cellular mediators that produce DNA fragmentation, research has been investigated to identify DNases of H. contortus. Among DNases detected, the DNases secreted from H. contortus adult worms occurred at 34, 36, 37 and 38.5 kDa.
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