Biological screening of some ferrocene derivative metal complexes
2006
Haque, M.D.E. (Rajshahi Univ. (Bangladesh). Inst. of Biological Sciences) | Hossen, M.D.F. (Rajshahi Univ. (Bangladesh). Dept. of Chemistry) | Islam, M.D.S. (Rajshahi Univ. (Bangladesh). Dept. of Genetics and Breeding) | Noman, A.S.M. (Chittagong Univ. (Bangladesh). Dept. of Biochemistry and Molecular Biology)
The aim of the present study was to investigate the antimicrobial and cytotoxic activities of five newly synthesized ferrocene based complexes [Mn {Fcd (COO)2}, A], [Co {Fcd (COO)2}, B], [Ni {Fcd (COO)2}, C], [Cu {Fcd (COO)2}, D] and [Zn {Fcd (COO)2}, E]. The maximum antibacterial (at the concentration 100 muG/disc) and antifungal (at the concentration 200 muG disc- 1) activities were shown by the manganese complex A followed by cobalt complex B. The minimum activities were shown by zinc complex E. The minimum inhibitory concentration of the complexes was determined against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Salmonella typhi and Shigella dysenteriae and the values of complex A were found between 16 - 32 muG mL-1. Brine shrimp bioassay lethality was carried out for cytotoxicity measurements of the complexes and the LC50 values were calculated after probit transformation of the resulting mortality data. Among the five complexes manganese complex A was showed highest cytotoxic effect, which is indicative of its probable effect on cancer cell lines.
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