Biotechnological production of organically bonded essential oligo and trace elements (EOTEs): from conventional toward modern biotechnology?
2006
Vrvic, M.M.(Faculty of Chemistry, Belgrade (Serbia)) | Matic, V.F.(University of Belgrade, Belgrade (Serbia). Institute of Chemistry, Technology and Metallurgy, Department of Chemistry)
Bioavailability of EOTEs is the key for their absorption in the digestive tract, transport and inclusion in the metabolism resp. their activity and it directly depends on the nature of the compound in which they are contained. This fact is the base for development of our biotechnological procedures for obtaining organically bonded EOTEs among which are: selenium, chromium(III), calcium, magnesium, calcium+magnesium, iron(II), zinc, potassium and silicon. Our strategy relates to the conventional biotechnologies for obtaining biomass (complex bioligands - biological agents) enriched by organically bonded EOTEs or application of biotechnological products as ligands and more rarely secretion of compounds containing them which is shown in this paper, as a review of results of our about twenty years long work in this field. Based on natural organic complex ligads several products of these our own biotechnologies are marketed as food supplements and non-prescription drugs only for oral application at present. Modern biotechnology which understands application of genetically engineering microorganisms (GEM) is not our trend for the future in this domain.
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