A pharmacokinetic study of sulphadimidine (sulphamethazine) alone and after its potentiation
2004
Cellarova, E.,University of Veterinary Medicine, Kosice (Slovak Republic) | Conkova, E. | Sutiak, V. | Neuschl, J.
The influence of trimethoprim administration as a potentiator of sulphadimidine in the blood plasma of twenty-four rabbits was investigated. The four groups of rabbits (A,B,C,D) were administered sulphadimidine. Group A - 30 mg.kg-1 b.w. orally (p.o.), Group B - the same dose intramuscularly (i.m.), Group C - 100 mg/kg b.w. p.o., Group D - the same dose i.m. The other four groups of rabbits (AP,BP,CP,DP) were administered sulphadimidine with trimethoprim in a dose 30 mg/kg b.w. of sulphadimidine and 6.4 mg/kg b.w. of trimethoprim p.o or i.m. (groups AP).
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