Intradermal vaccination and experimental infection of Actinobacillus pleuropneumoniae in pigs
2007
Bernardy, J.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic) | Nechvatalova, K.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Krejci, J.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Kudlackova, H.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic) | Brazdova, I.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic) | Faldyna, M.,Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic)
The aim of this study was to compare intradermal (ID) and intramuscular (IM) vaccinations against Actinobacillus pleuropneumoniae infection in pigs. An ID vaccine containing a lipopolysaccharide, outer membrane protein and toxins was used diluted or concentrated. The challenge infection was tested three weeks after revaccination. The immunity was evaluated by the ELISA method after vaccination, revaccination and chalenge infection in blood. The damaged surface of lungs was measured after autopsy of the animals. The comparison of data obtained from clinical monitoring, gross pathology and by the ELISA method showed a discrepancy between the results. High levels of specific IgG antibodies did not provide better protection of the animals against the infection. Nevertheless, the experiment demonstrated that the ID vaccination may be as efficient as the IM one. The most efficient concentrations were in groups ID1/3, ID and ID2/1. Three times diluted ID dose was more efficient than more concentrated ones.
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