Expression of cyclooxygenase-2 and nitric oxide synthase-1 in kidneys of dogs and cats with renal failure
2007
Yabuki, A.(Kagoshima Univ. (Japan). Faculty of Agriculture) | Endo, Y. | Fujiki, M. | Miyoshi, N. | Matsumoto, M. | Suzuki, S.
In the present study, we investigated the kidneys of necropsied dogs (n=8) and cats (n=6) histopathologically and immunohistochemically in order to clarify whether expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase-1 (NOS-1) correlate with the progression of renal failure. Histopathological changes and expressions of COX-2 and NOS-1 in the kidneys were evaluated by quantitative manners. In the dogs, a high correlation between the number of COX-2 positive cells and the score of a-smooth muscle actin (SMA), a marker of renal fibrosis progression, was detected. On the contrary, a high correlation was detected between the number of NOS-1 positive cells and the score of SMA in the cats. The present findings suggested that the pathological mechanisms in the progression of renal failure are different between dogs and cats.
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