Detection of genetic toxicity in secondary metabolites of Fusarium strains isolated from domestic animal feeds
2006
Arakawa, K.(National Inst. of Infectious Diseases, Tokyo (Japan)) | Tanaka, N. | Takatori, K. | Sawada, T.
Metabolites of 8 species 53 strains of Fusarium isolated from domestic animal feeds were tested in Salmonella mutagenicity test with and without metabolic activation. Mutagenic activity was detected on crude extracts of 5 species 13 strains of them; F. graminearum, F. nivale, F. tricinctum, F. semitectum, and F. oxysporum. From the result of thin layer chromatography, it seems that those mutagenic metabolites were the same compound. Moreover, the highest mutagenic activity extract was tested in chromosome aberrations in human lymphocytes and dominant lethal test in mice. It was detected chromatid type aberrations; gap and brake, in human lymphocytes, and induction of dominant lethality on late spermatids and sperms in mice.
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