Inhibitory Effect of the Methanolic Extract of Symphyocladia latiuscula on the Growth of HT-29 Human Colon Cancer Cells
2007
Kim, E.J. (Hallym University, Chuncheon, Republic of Korea), E-mail: [email protected] | Park, S.Y. (Hallym University, Chuncheon, Republic of Korea) | Hong, J.E. (Hallym University, Chuncheon, Republic of Korea) | Shin, M.J. (Hallym University, Chuncheon, Republic of Korea) | Lim, S.S. (Hallym University, Chuncheon, Republic of Korea) | Shin, H.K. (Hallym University, Chuncheon, Republic of Korea) | Yoon, J.H. (Hallym University, Chuncheon, Republic of Korea)
In the present study, twenty eight marine algae species were evaluated for their antiproliferative effect on HT-29 human colon cancer cells. Among these, the methanolic extract of Symphyocladia latiuscula (SL Ex) showed the highest inhibitory activity on HT-29 cell growth. In this study, we examined the mechanism by which SL Ex inhibited the HT-29 cell growth. Cells were cultured with various concentrations of (0~20 ㎍/mL) SL Ex. The SL Ex substantially decreased the viable cell numbers and induced apoptosis of HT-29 cells in a dose-dependent manner.
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