Effects of Fucoidan on Neuronal Cell Proliferation: Association with NO Production through the iNOS Pathway
2007
Lee, H.R. (Sungkyunkwan University, Suwon, Republic of Korea) | Do, H. (Sungkyunkwan University, Suwon, Republic of Korea) | Lee, S.R. (Sungkyunkwan University, Suwon, Republic of Korea) | Sohn, E.S. (Korea Institute of Science and Technology Information, Seoul, Republic of Korea) | Pyo, S.K. (Sungkyunkwan University, Suwon, Republic of Korea) | Son, E.H. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: [email protected]
Fucoidan, that is high-molecular-weight sulfated polysaccharides extracted from brown seaweeds has been shown to elicit various biological activities. Here, we investigated the effects of fucoidan on cell proliferation and nitric oxide (NO) production in neuronal blastoma cell (SH-SY5Y). In the present study, we demonstrated that fucoidan treatment resulted in increase of cell proliferation and NO production. When cells were treated with amyloid-β (Aβ) in the absence or presence of fucoidan, fucoidan recovered the cell viability decreased by Aβ peptides.
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