Protective Effect of Methanolic Extracts from Dendrobium nobile Lindl. on H₂O₂-induced Neurotoxicity in PC12 cells
2007
Yoon, M.Y. (Kyungnam University, Masan, Republic of Korea) | Kim, J.Y. (Kyungnam University, Masan, Republic of Korea) | Hwang, J.H. (Kyungnam University, Masan, Republic of Korea) | Cha, M.R. (Kyungnam University, Masan, Republic of Korea) | Lee, M.R. (Kyungnam University, Masan, Republic of Korea) | Jo, K.J. (Kyungnam University, Masan, Republic of Korea) | Park, H.R. (Kyungnam University, Masan, Republic of Korea), E-mail: [email protected]
The neuroprotective effect of methanolic extracts from Dendrobium nobile Lindl. (DME) against H₂O₂-induced neurotoxicity in PC12 cells was investigated. The treatment of PC12 cells with various DME concentrations under H₂O₂ resulted in the induction of protective effect in a dose-dependent manner, as determined by the results of an MTT reduction assay, an LDH release assays, and a morphological assay. Interestingly, we also detected reduction of apoptotic bodies and inhibition of caspase-3 activity by DME in H₂O₂-induced PC12 cells.
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