The effect of transgenesis on milk production of rabbits
2008
Dragin, S., Poljoprivredni fakultet, Novi Sad (Serbia) | Bozic, A., Poljoprivredni fakultet, Novi Sad (Serbia) | Chrenek, P., Research Institute of Animal Production, Nitra (Slovak Republic)
Basic objective of this research was to compare quantity and quality of the milk from transgenic rabbits expressing recombinant human factor VIII (hFVIII) with that of non-transgenic rabbit females of the same age during 30 days of lactation. Transgenic individuals were generated by the microinjection of foreign DNA (mWAP-hFVIII gene construct) into the egg in order to produce transgenic animals. New Zealand White transgenic rabbits (F1 and F2 generation) were obtained after mating of transgenic founder rabbits with non-transgenic rabbits. Comparison of milk production showed that significant higher milk production at day 15 and 20 of the first lactation was in non-transgenic females, but at the same days of the second lactation higher milk yield was measured in transgenic does. Significant higher content of milk fat was determined in transgenic milk and, on the other hand, higher content of lactose in non-transgenic milk composition was found. Excepting these findings, our results did not reveal any negative effect of the mWAP-hFVIII trangene on the rabbit milk yield of transgenic females comparing with non-transgenic females.
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