Effect of acute adrenalectomy on rat liver glucocorticoid receptor
2006
Isenovic, E.R., Vinca Institute of Nuclear Sciences, Belgrade (Serbia). Laboratory of Radiobiology and Molecular Genetics | Radojcic, M. | Zakula, Z. | Koricanac, G. | Ribarac-Stepic, N., Vinca Institute of Nuclear Sciences, Belgrade (Serbia). Laboratory of Molecular Biology and Endocrinology
In this study liver tissues from male Wistar rats were used as an experimental model to study structural and functional properties of glucocorticoid receptor (GR) in the absence of glucocorticoid hormones (GC). Results show that acute adrenalectomy (ADX) significantly increases the number of GR binding sites and GR protein content. In addition, acute ADX stimulates increase in stability of the GR, decrease in stability of the glucocorticoid-receptor complex (G-R), and changes in accumulation of the G-R complex in nuclei and its cellular distribution.
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