[Evaluation of biological activity of timogen for recover of sexual cycle in cows with ovary hypofunction]
2007
Cherepchenko, E.O. | Bezborodov, E.N., Belgorod State Agricultural Academy (Russian Federation)
The immunological activity of timogen was evaluated for ovary hypofunction in cows caused with dysfunction hypothalamo-pituitary axis and adrenal cortex. The dynamic of steroid hormones is determined: estradiol-17-beta, progesterone and cortisol in blood serum of cows before and after administration of timogen (at days 5, 10 and 18), as well as hematological values including blood biochemistry. Timogen administered at the dose of 20.0 ml/head/day for 10 days promoted reducing the level of progesterone (by 59%) and increasing cortisol – by 48.5% without influencing estradiol. The biocorrecting effect of tiomogen blocking twice the activity of progesterone stimulated folliculogenesis, at the same time increasing the concemtration of cortisol. It testified to an effect of the immunomodulator through hypophysis on adrenal cortex. Cortisol inhibited the development of an inflammatory process in cows" ovaries due to the stimulation of secretion with lypocortin monocytes. An analysis of hematological values has found a stimulating effect of timogen on cellular and humoral immunity of cows. The observation of sexual cycle after the administration of timogen to cows has shown that 60% of animals come in estrus in 15 days after completion of the timogen treatment and were impregnated. Timogen can be used as a therapeutic and prophylactic preparation for infertility of cows with ovary hypofunction.
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