The membrane active antibiotics effects on rat heart myocardium
2006
Gopcevic, K., Shool of Medicine, Belgrade (Serbia) | Gojgic-Cvijovic, G., Institute of Chemistry, Tehnology and Metallurgy, Belgrade (Serbia) | Pavlovic, M., Shool of Medicine, Belgrade (Serbia) | Milicevic, Z., Shool of Medicine, Belgrade (Serbia) | Stevanovic, D., Shool of Medicine, Belgrade (Serbia)
The effect of some membrane active ionophoric antibiotics on the amplitide of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 micromol/L exerts a positive inotrophic effect with its maximal value (+28%) 15 minutes after application. Amphotericin B in a concentration of 1.08 micromol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 micromol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.
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