A tissue-implant reaction associated with subcutan implantation of alpha-tricalcium phosphate, dental ceramic hydroxyapatite bioceramics in rats
2008
Stojanovic, D., Faculty of Technology and Metallurgy, Belgrade (Serbia) | Janackovic, Dj., Faculty of Technology and Metallurgy, Belgrade (Serbia) | Markovic, D., Faculty of Veterinary Medicine, Belgrade (Serbia). Department of Histology | Tasic, G., Clinical Center of Serbia, Belgrade (Serbia). Institute of Neurosurgery | Aleksandric, B., Shool of Medicine, Belgrade (Serbia). Institute of Forensic Medicine | Kojic, Z., School of Medicine, Belgrade (Serbia). Institute of Medical Physiology
Calcium phosphate ceramics are among the more commonly used an biocompatible ceramics. Recently, we have synthesized a new calcium phopshate ceramic, alpha-tricalcium phosphate (a TCP). The aim of this study was to assess the biocompatibility of this original, in laboratory condition modified, newly synthesized aTCP ceramic, by carefully evaluating the inflammatory reaction of soft tissue in response to its subcutaneous implantation, and by comparing this result with the results of already widely used virtually non-toxic, non-immunogenic and almost chemically inert dental (DC) and hydroxy apatite (HAP) ceramics.
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