Retinoic acid as a therapy for coushing's disease in dogs: evaluation of liver enzymes during treatment
2007
Ortemberg, L., Universidad de Buenos Aires (Argentina). Facultad de Ciencias Veterinarias | Loiza, M. | Martiarena, B.M. | Cabrera-Blatter, M. F. | Ghersevich, M. C. | Castillo, V.
Recent studies have demonstrated that retinoic acid is capable to control the Pituitary-Dependent Hyperadrenocorticism by its action on the ACTH-secreting pituitary tumour. Because the hepatotoxic effects of retinoic acid have been reported, the hepatograms of dogs with Cushing’s Syndrome treated with this medicine were analysed during 180 days of therapy and compared with dogs which received Ketoconazole as an alternative treatment. No animal showed hepatoxicity signs with both treatments. Dogs treated with retinoic acid showed a decrease (not significant) of the alkaline phosphatise (AP), without any changes in the other group. Alanine amine transferase (ALT) was reduced after 180 days vs. 0 days (P = 0.04) in the retinoic group. On the other hand, this enzyme increased in the Ketoconazole group (P0.02). Alanine aspartic transferase (AST) did not show any variations in the retinoic group, remaining within the baseline values. In the Ketoconazole group a significant increase (P0.03) was seen after 180 days vs. 0 day. The reduction of ALT and AP in the retinoic group is related to the decrease of ACTH (r
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