Antimicrosporidial effect of albendazole in rabbits experimentally infected by Encephalitozoon cuniculi
2005
Neuschl, J.(University of Veterinary Medicine, Kosice (Slovak Republic) | Conkova, E. | Cellarova,E. | Saly,J.
In adult rabbits of the New Zealand white breed, female sex, development of experimentally induced encephalitozoonosis (Encephalitozoon cuniculi) has been observed after the therapeutic affect by albendazole compared with the positive and negative control groups. The negative control group were not infected by microsporidia. The positive control group were infected by Encephalitozoon cuniculi microsporidia with a single intraperitoneal dose of 5.10E7/ml.The experimental group after inoculaction with Encephalitozoon cuniculi in the same dose and way as in the positive control group, albendazole was subsequently applied. The experimental group, albendazole was applied in the form of Aldifal 2.5% susp. in a dose 5 mg/kg of b. w. per os with tube. Albendazole has been administered to animals from the experimental group from day 7 after inoculation by Encephalitozoon cuniculi, twice a week for 11 weeks and overall this was applied 21 times. The titre of antibodies was determined by the IFAT method.
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