Pathological effects of benomyl in male Japanese quails (Coturnix japonica)
2008
Khan, M.Z.,University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Pathology | Sajjad-Ul-Hassan,University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Pathology | Mahmood, F.,University of Agriculture, Faisalabad (Pakistan). Dept. of Veterinary Pathology | Khan, Q.M.,National Inst. for Biotechnology and Genetic Engineering | Muhammad, G.,University of Agriculture, Faisalabad (Pakistan). Clinical Medicine and Surgery | Javed, I.,University of Agriculture, Faisalabad (Pakistan). Physiology and Pharmacology
The purpose of this study was to observe the pathological and genotoxic effects of a systemic fungicide, Benomyl [methyl 1-(butyl carbamoyl)-2 benzimidazole carbamate] in male Japanese quails. Benomyl at dose rates of 0, 100, 400 and 1,000 mg/kg was administered into crops for 8 consecutive days. A significant decrease in feed intake, body weight and relative weight of testes was observed in benomyl-administered quails in a dose related manner. The size of testes decreased in benomyl-treated quails. Microscopically, seminiferous tubules of testes exhibited a decreased number of spermatocytes, necrotic spermatids and syncytial cell formation. The number of quails developing testicular alterations increased in a dose-related pattern. These alterations reversed following a withdrawal of benomyl with the exception of the 1,000 mg benomyl group, where these persisted till the end of the experiment (56th day). The mean tail length of the comets produced by leukocytes in single cell gel electrophoresis of 0, 100 and 400 mg dose level groups were 3.48, 3.24 and 3.29 microm, respectively. The mean tail length of comets of the 1,000 mg dose level group was 12.03 microm and significantly higher than in all other groups indicating DNA strand breaks at this dose level. These results suggested gonadotoxic effects of benomyl and also a possible genotoxic effect at 1,000 mg/kg level in Japanese quails.
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